Monday, April 27, 2015

clickable match ups for the first round

Elise Biesboer holds the ultimate prize following the triumph of sonic hedgehog in Protein of the Year 2014. Whose name will be added to the Jane Richardson Cup in 2015?

Voting begins soon. If you are interested in participating, please submit your request to arnoys_at_calvin_dot_edu.

The Quest for the Jane Richardson Cup

Linus Pauling Regional:

CD4 vs. hiFABP
YfiR vs. BMP-7

Dorothy Crowfoot Hodgkin Regional:

Christian Anfinsen Regional:

Max Perutz Regional:

the bracket is here!

Sunday, April 26, 2015

stories of the bracket

stories of the bracket

Jane Richardson was trained as a philosopher and a physicist but soon turned to studies of protein structures. She developed a means of representing α-helices and β-sheets in tertiary structures that is now the standard for protein structures, and she has continued her work as a pioneer in protein structure study and representation. She is now a member of the National Academy of Sciences, among other awards. In honor of her beautiful illustrations that have become the standard for understanding structure/function relationships, the prize for Protein of the Year is named “The Jane Richardson Cup.”

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Linus Pauling won a Nobel Prize in Chemistry in part for predicting the structures of α-helices and β-sheets in proteins. He won a second Nobel Prize in Peace for his work on nuclear disarmament and the Partial Test Ban Treaty which limited above ground nuclear testing . He was close to a third prize for the structure of DNA, but Watson and Crick beat him to it.

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Dorothy Crowfoot Hodgkin was a pioneer in x-ray crystallography, and many of the early protein crystallographers credit her work as a forerunner for theirs. She solved the first structures of vitamin B12 and insulin, among other things, and she won a Nobel Prize in Chemistry for this work in 1964.

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Christian Anfinsen won a Nobel Prize for his elegant experiments demonstrating that the information necessary for ribonuclease folding was contained in its amino acid sequence. We know that this holds for other proteins, though sixty years later we still do a poor job of predicting a protein’s structure from its sequence.

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Max Perutz is another giant in protein x-ray crystallography, having solved the initial structures of both oxy- and deoxyhemoglobin and proposing the Perutz mechanism by which hemoglobin switches between the R state and T state to bind and release oxygen. Along with John Kendrew, he received the Nobel Prize for his work in studying the structures of globular proteins.

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Friday, April 24, 2015

Proteins in Red Shirts

What will the first round look like? For the first round our proteins will need opponents from outside of our class.

If you don't know the reference, check out What's in a name.